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When it comes to medication there is always a question of its effectiveness. How well any medication works varies from one individual to another. Researchers decided to examine if diet and lifestyle can contribute to the variation of effectiveness for drugs.

Dr. Daniela Delneri, Faculty of Life Sciences, University of Manchester, devised a clever study involving baker’s yeast to explore the relationship between environment and genetic background. One of the two gene copies was removed from the yeast–think of it as removing one parent’s set of genes in a human. The mutant genes were given different diets and analyzed for their fitness.

If the removed gene copy was important the researchers expected a reduction in their fitness. Surprisingly, removing one copy of certain genes produced yeast cells that grew faster and were healthier. Further research showed that the genes involved with the increased fitness were also involved in the proteasome.

Proteasome helps maintain an equilibrium of the cell. When the equilibrium is thrown out of balance it can result in a number of diseases, including cancer, diabetes, Huntington’s, Alzheimer’s, and Parkinson’s. For example, rapidly-growing cancerous cells have a high proteasome activity that makes the cancerous cells immortal; blocking or inhibiting the proteasome’s actions are currently used as therapeutic compounds.

Researchers found that reduced proteasome activity could be either advantageous or damaging to the cell; depending on the nutrients available to it in the surrounding environment. As a consequence the researchers suggest when therapeutic drugs are administered to alter the proteasome activity a person’s diet and lifestyle should be taken into consideration to assure the correct beneficial effect.

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  • Mary R. March 7, 2018, 6:52 pm

    My mother was diagnosed with ALS in May 2014. Her doctor put her on riluzole, letting her know there was no cure but the medication might provide her a few more months of delayed symptoms. ALS progresses at different rates and affects different body parts first. My mother, being 80 at the time, fell into a category of what they call “fast progression” (older female). Her arms weakened first, then her hands, her mouth, and throat, and finally her lungs. Throughout her two-and-a-half-year ordeal, she was able to walk with assistance. All the while she continued to take the riluzole. If it bought my mother any time, we will never know. Her neurologist told us that if she couldn’t afford it, there was no real need to take it. She lost touch with reality. Suspecting it was the medication I took her off the riluzole (with the doctor’s knowledge) and started her on the ALS natural herbal formula we ordered from GREEN HOUSE HERBAL CLINIC, We spoke to few people who used the treatment here in Canada and they all gave a positive response, her symptoms totally declined over a 7 weeks use of the Green House ALS disease natural herbal formula. She is now almost 83 and doing very well, the disease is totally reversed!